Research Papers by Augustinus Bader

The use of primary hepatocyte cultures is well established for the study of drug metabolism and drug-drug interactions. However, the application of these cells in hybrid artificial liver systems has been hampered by the gradual loss of differentiated function in vitro. Therefore, several hepatic cul

These results demonstrate that the oxygen permeable membrane bioreactor utilized in our study allows obtaining a small-scale organization of human hepatocytes in a micro architecture similar to that in vivo. This study attested the feasibility of the small-scale flat membrane bioreactor as a simple

Novel PEEK-WC-PU membrane results an interesting material which is able to support the long-term maintenance and differentiation of human hepatocytes. These results evidenced a good performance of PEEK-WC-PU membranes in terms of albumin and urea synthesis. Moreover the experiments with the bioreact